The severity of coronary artery disease evaluated by central systolic pressure and fractional diastolic pressure

BACKGROUND Central pulse pressure, pulse pressure index and fractional pulse pressure have been confirmed to be associated with increased risk of cardiovascular disease, but if the severity of cardiovascular disease, specifically for the coronary artery disease, is evaluated by central systolic pressure and fractional diastolic pressure has been not well studied. AIMS This study was designed to examine if central systolic pressure and fractional diastolic pressure could act as a predicting factor for the severity of coronary artery disease. PATIENTS AND METHODS A total of 310 patients were included in this study. 154 patients were diagnosed with coronary artery disease, and 156 with non-coronary artery disease, which was confirmed with diagnostic coronary angiography. The average age and sex in the two groups were same. RESULTS Age, peripheral and central systolic blood pressure, fractional systolic pressure, and fractional diastolic pressure were significantly higher in the patients with coronary artery disease (P<0.05). The central fractional systolic pressure and fractional diastolic pressure were abnormal in the patients with coronary artery disease. Central fractional systolic pressure and fractional diastolic pressure presented a positive correlation between them and coronary Gensini Score (P<0.05), in the patients with coronary artery disease. CONCLUSIONS The severity of coronary artery disease may be predicted by examination of central fractional systolic pressure and fractional diastolic pressure.